The Challenge

Antimicrobial resistance (AMR) represents one of the most pressing threats to global health security. Resistant pathogens are spreading exponentially, undermining the effectiveness of antibiotics and other antimicrobial treatments that modern medicine depends upon. The implications extend beyond human health to encompass food security and environmental stability across the One Health spectrum.

Current challenges include:

• Limited Resources: Fragmented funding and attention prevent comprehensive, sustained AMR interventions

• Imbalanced Perspectives: Policy discussions often lack representation from all affected sectors—human health, animal agriculture, and environmental science

• Coordination Gaps: Despite progress, efforts remain siloed, threatening the sustainability of gains made to date

• Policy Vacuum: There is an urgent need for consensus-based, actionable policy recommendations that reflect the full AMR community

Without coordinated action, we risk losing our ability to perform routine surgeries, treat common infections, and maintain food production systems that rely on effective antimicrobial treatments.

Established in September 2025, the AMR Strategic Coalition (ASC) unites leading U.S. experts across One Health sectors to build stakeholder consensus, amplify voices, and deliver policy solutions to combat antimicrobial resistance (AMR). Led by trusted independent leaders with decades of combined deep federal policy, diplomacy, and scientific experience advancing AMR efforts, the ASC assembles partners to develop critical evidence-based and holistic policy postures that are reflective of the interdisciplinary AMR community in the United States.